abstract：PURPOSE:Evaluation of the long-term prognostic value of myocardial perfusion imaging (MPI) in octogenarians. METHODS:Six hundred and twenty-nine octogenarians [51% previous myocardial infarction (MI) or revascularization] who underwent single-isotope MPI (78% 201Tl, 22% 99mTc-tetrofosmin) with exercise (38% Bruce, 2% ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Katsikis A,Theodorakos A,Manira V,Papaioannou S,Kolovou G,Voudris V,Koutelou M

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Rhenium-188-HEDP is a beta-emitting radiopharmaceutical used for palliation of metastatic bone pain. We investigated whether the addition of rhenium-188-HEDP to docetaxel/prednisone improved efficacy of chemotherapy in patients with CRPC. METHODS:Patients with progressive CRPC and osteoblastic bone metastas...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Dodewaard-de Jong JM,de Klerk JMH,Bloemendal HJ,Oprea-Lager DE,Hoekstra OS,van den Berg HP,Los M,Beeker A,Jonker MA,O'Sullivan JM,Verheul HMW,van den Eertwegh AJM

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Our aim was to assess whether 18F-NaF PET/CT is able to predict progression of the CT calcium score. METHODS:Between August 2007 and November 2015, 34 patients (18 women, 16 men; age, mean ± standard deviation, 57.5 ± 13.9 years; age range 19-78 years) with malignancy or orthopaedic disease were enrolled in th...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ishiwata Y,Kaneta T,Nawata S,Hino-Shishikura A,Yoshida K,Inoue T

更新日期：2017-08-01 00:00:00

abstract：PURPOSE/BACKGROUND:[18F]fluoroethylcholine (18FECH) has been shown to be a valuable PET-tracer in recurrent prostate cancer (PCa), but still has limited accuracy. RM2 is a gastrin-releasing peptide receptor (GRPr) antagonist that binds to GRPr on PCa cells. Recent studies suggest that GRPr imaging with PET/CT is a prom...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Wieser G,Popp I,Christian Rischke H,Drendel V,Grosu AL,Bartholomä M,Weber WA,Mansi R,Wetterauer U,Schultze-Seemann W,Meyer PT,Jilg CA

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Cervical dystonia (CD) is associated with tremor/jerks (50%) and psychiatric complaints (17-70%). The dopaminergic system has been implicated in the pathophysiology of CD in animal and imaging studies. Dopamine may be related to the motor as well as non-motor symptoms of CD. CD is associated with reduced striat...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Zoons E,Tijssen MAJ,Dreissen YEM,Speelman JD,Smit M,Booij J

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Radiopharmaceutical extravasation can potentially lead to severe soft tissue damage, but little is known about incidence, medical consequences, possible interventions, and effectiveness of these. The aims of this study are to estimate the incidence of extravasation of diagnostic and therapeutic radiopharmaceuti...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van der Pol J,Vöö S,Bucerius J,Mottaghy FM

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:To assess the role of single-photon emission computed tomography with computed tomography (SPECT-CT) for the identification of sentinel lymph nodes (SLNs) in patients with early stage (T1-T2) oral cancer and a clinically negative neck (cN0). METHODS:In addition to planar lymphoscintigraphy, SPECT-CT was perfor...

journal_title：European journal of nuclear medicine and molecular imaging

authors： den Toom IJ,van Schie A,van Weert S,Karagozoglu KH,Bloemena E,Hoekstra OS,de Bree R

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:Ischemia in hypertrophic cardiomyopathy (HCM) is caused by coronary microvascular dysfunction (CMD), which is detected by measuring myocardial blood flow (MBF) with PET. Whether CMD may be associated with ischemic left ventricular (LV) dysfunction is unclear. We therefore assessed LV ejection fraction (EF)...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sciagrà R,Calabretta R,Cipollini F,Passeri A,Castello A,Cecchi F,Olivotto I,Pupi A

更新日期：2017-05-01 00:00:00

abstract：INTRODUCTION:A targeted theragnostic approach based on increased expression of prostate-specific membrane antigen (PSMA) on PC cells is an attractive treatment option for patients with metastatic castration-resistant prostate cancer (mCRPC). METHODS:Ten consecutive mCRPC patients were selected for 177Lu-PSMA617 therap...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Scarpa L,Buxbaum S,Kendler D,Fink K,Bektic J,Gruber L,Decristoforo C,Uprimny C,Lukas P,Horninger W,Virgolini I

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The clinical problem in suspected aortoiliac graft infection (AGI) is to obtain proof of infection. Although 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography scanning (PET) has been suggested to play a pivotal role, an evidence-based interpretation is lacking. The objective of this retrospective...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Saleem BR,Beukinga RJ,Boellaard R,Glaudemans AW,Reijnen MM,Zeebregts CJ,Slart RH

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:To report on imaging findings using 68Ga-PSMA-HBED-CC PET in a series of 19 breast carcinoma patients. METHODS:68Ga-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging examinations and analyzed as to lesion location and progesterone receptor status. RESULTS:Out of 81 tumo...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sathekge M,Lengana T,Modiselle M,Vorster M,Zeevaart J,Maes A,Ebenhan T,Van de Wiele C

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:In Alzheimer's disease (AD), increased metabolism of monoamines by monoamine oxidase type B (MAO-B) leads to the production of toxic reactive oxygen species (ROS), which are thought to contribute to disease pathogenesis. Inhibition of the MAO-B enzyme may restore brain levels of monoaminergic neurotransmitters,...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sturm S,Forsberg A,Nave S,Stenkrona P,Seneca N,Varrone A,Comley RA,Fazio P,Jamois C,Nakao R,Ejduk Z,Al-Tawil N,Akenine U,Halldin C,Andreasen N,Ricci B

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Our aim was to assess the prognostic and predictive value of somatostatin receptor 2 (sstr2) in neuroendocrine tumors (NETs). METHODS:We established a tissue microarray and imaging database from NET patients that received sstr2-targeted radiopeptide therapy with yttrium-90-DOTATOC, lutetium-177-DOTATOC or alte...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Brunner P,Jörg AC,Glatz K,Bubendorf L,Radojewski P,Umlauft M,Marincek N,Spanjol PM,Krause T,Dumont RA,Maecke HR,Müller-Brand J,Briel M,Schmitt A,Perren A,Walter MA

更新日期：2017-03-01 00:00:00

abstract：:Multiple myeloma (MM) is characterized by a monoclonal plasma cell population in the bone marrow. Lytic lesions occur in up to 90 % of patients. For many years, whole-body X-ray (WBX) was the method of choice for detecting skeleton abnormalities. However, the value of WBX in relapsing disease is limited because lesion...

journal_title：European journal of nuclear medicine and molecular imaging

authors： de Waal EGM,Glaudemans AWJM,Schröder CP,Vellenga E,Slart RHJA

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the usefulness of L-4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) as a tumor-specific probe, in comparison to 18F-FDG and 11C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers. MET...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Watabe T,Ikeda H,Nagamori S,Wiriyasermkul P,Tanaka Y,Naka S,Kanai Y,Hagiwara K,Aoki M,Shimosegawa E,Kanai Y,Hatazawa J

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To determine the metabolic profiles of the translocator protein ligands PBR102 and PBR111 in rat and human microsomes and compare their in vivo binding and metabolite uptake in the brain of non-human primates (Papio hamadryas) using PET-CT. METHODS:In vitro metabolic profiles of PBR102 and PBR111 in rat and hu...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Eberl S,Katsifis A,Peyronneau MA,Wen L,Henderson D,Loc'h C,Greguric I,Verschuer J,Pham T,Lam P,Mattner F,Mohamed A,Fulham MJ

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To test the performance of sequential 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in predicting survival after sunitinib therapies in patients with cancer of unknown primary (CUP). METHODS:CUP patients were enrolled for sequential PET/CT scanning for sunitinib and a con...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ma Y,Xu W,Bai R,Li Y,Yu H,Yang C,Shi H,Zhang J,Li J,Wang C,Xiao J

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To investigate changes in sympathetic activity, perfusion, and left ventricular (LV) functionality in takotsubo cardiomyopathy (TTC) patients from onset (T0) to post-onset conditions at 1 month (T1), 1-2 years (T2, T3). METHODS:Twenty-two patients (70 ± 11 years) underwent serial gated single photon emission t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sestini S,Pestelli F,Leoncini M,Bellandi F,Mazzeo C,Mansi L,Carrio I,Castagnoli A

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:Nitroglycerin (NTG) is a vasodilating drug, which increases tumor blood flow and consequently decreases hypoxia. Therefore, changes in [18F] fluorodeoxyglucose positron emission tomography ([18F]FDG PET) uptake pattern may occur. In this analysis, we investigated the feasibility of [18F]FDG PET for response ass...

journal_title：European journal of nuclear medicine and molecular imaging

authors： de Jong EE,van Elmpt W,Leijenaar RT,Hoekstra OS,Groen HJ,Smit EF,Boellaard R,van der Noort V,Troost EG,Lambin P,Dingemans AC

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:The relationship between tumor metabolism and stage, subcutaneous and visceral fat thickness, and their glucose metabolism and overall survival in patients recently diagnosed with pancreatic carcinoma was assessed. METHODS:Thirty-eight consecutive patients were studied. Subcutaneous fat thickness (SFT), viscer...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Van de Wiele C,Van Vlaenderen M,D'Hulst L,Delcourt A,Copin D,De Spiegeleer B,Maes A

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:The extent of neovascularization determines the clinical outcome of coronary artery disease and other occlusive cardiovascular disorders. Monitoring of neovascularization is therefore highly important. This review article will elaborately discuss preclinical studies aimed at validating new nuclear angiogenesis ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hendrikx G,Vöö S,Bauwens M,Post MJ,Mottaghy FM

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:The study aims to investigate the role of 18F-alfatide positron emission tomography/computed tomography (PET/CT) in predicting the short-term outcome of concurrent chemoradiotherapy (CCRT) in patients with advanced non-small cell lung cancer (NSCLC). METHODS:Eighteen patients with advanced NSCLC had undergone ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Luan X,Huang Y,Gao S,Sun X,Wang S,Ma L,Teng X,Lu H,Yu J,Yuan S

更新日期：2016-12-01 00:00:00

abstract：:The trade-off between resolution and count sensitivity dominates the performance of standard gamma cameras and dictates the need for relatively high doses of radioactivity of the used radiopharmaceuticals in order to limit image acquisition duration. The introduction of cadmium-zinc-telluride (CZT)-based cameras may o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Agostini D,Marie PY,Ben-Haim S,Rouzet F,Songy B,Giordano A,Gimelli A,Hyafil F,Sciagrà R,Bucerius J,Verberne HJ,Slart RH,Lindner O,Übleis C,Hacker M,Cardiovascular Committee of the European Association of Nuclear Medicine (E

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Sympathetic nervous system (SNS) hyperactivity is a salient characteristic of chronic heart failure (HF) and contributes to the progression of the disease. Iodine-123 meta-iodobenzylguanidine (123I-mIBG) imaging has been successfully used to assess cardiac SNS activity in HF patients and to predict prognosis. I...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Rengo G,Pagano G,Vitale DF,Formisano R,Komici K,Petraglia L,Parisi V,Femminella GD,de Lucia C,Paolillo S,Cannavo A,Attena E,Pellegrino T,Dellegrottaglie S,Memmi A,Trimarco B,Cuocolo A,Filardi PP,Leosco D,Ferrara N

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Radioguided sentinel lymph node biopsy (SLNB) is the standard of care in breast cancer and melanoma. Additional preoperative Single-photon emission computed tomography (SPECT/CT) for improved anatomical co-registration of the SLNs causes additional radiation exposure and is time-consuming and expensive. The aim...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bluemel C,Safak G,Cramer A,Wöckel A,Gesierich A,Hartmann E,Schmid JS,Kaiser F,Buck AK,Herrmann K

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:In this retrospective review of prospectively collected data, we sought to investigate whether early FDG-PET assessment of treatment response based on total lesion glycolysis measured using a systemic approach (TLG-S) would be superior to either local assessment with EORTC (European Organization for Research an...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ho KC,Fang YD,Chung HW,Liu YC,Chang JW,Hou MM,Yang CT,Cheng NM,Su TP,Yen TC

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:This study was designed to determine safety, tolerability, and radiation burden of a [(68)Ga]NODAGA-RGD-PET for imaging integrin αvβ3 expression in patients with hepatocellular carcinoma (HCC) and liver cirrhosis. Moreover, metabolic stability and biokinetic data were compiled. METHODS:After injection of 154-1...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Haubner R,Finkenstedt A,Stegmayr A,Rangger C,Decristoforo C,Zoller H,Virgolini IJ

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To study the effect of adjuvant lithium on serum thyroxine (T4) concentrations in patients treated with radioactive iodine (RAI) therapy in our environment. METHODS:This was a prospective simple randomized comparative, experimental cohort study of patients with hyperthyroidism referred for RAI ablation therapy...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hammond EN,Vangu MD

更新日期：2016-10-01 00:00:00

abstract：:Physiologically increased pancreatic uptake at the head/uncinate process is observed in more than one-third of patients after injection of one of the three (68)Ga-labelled octreotide-based peptides used for somatostatin (sst) receptor (r) imaging. There are minor differences between these (68)Ga-sstr-binding peptides ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Virgolini I,Gabriel M,Kroiss A,von Guggenberg E,Prommegger R,Warwitz B,Nilica B,Roig LG,Rodrigues M,Uprimny C

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Fluorescence guidance is an upcoming methodology to improve surgical accuracy. Challenging herein is the identification of the minimum dose at which the tracer can be detected with a clinical-grade fluorescence camera. Using a hybrid tracer such as indocyanine green (ICG)-(99m)Tc-nanocolloid, it has become...

journal_title：European journal of nuclear medicine and molecular imaging

authors： KleinJan GH,Bunschoten A,van den Berg NS,Olmos RA,Klop WM,Horenblas S,van der Poel HG,Wester HJ,van Leeuwen FW

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To determine the value of (68)Ga-DOTA-TOC and (18)F-FDG PET/CT for initial and follow-up evaluation of patients with neuroendocrine tumour (NET) treated with peptide receptor radionuclide therapy (PRRT). METHODS:We evaluated 66 patients who had histologically proven NET and underwent both PRRT and three combin...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nilica B,Waitz D,Stevanovic V,Uprimny C,Kendler D,Buxbaum S,Warwitz B,Gerardo L,Henninger B,Virgolini I,Rodrigues M

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:The histamine H3 receptors are presynaptic neuroreceptors that inhibit the release of histamine and other neurotransmitters. The receptors are considered a drug target for sleep disorders and neuropsychiatric disorders with cognitive decline. We developed a novel PET ligand for the H3 receptors, [(11)C]TASP0410...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kimura Y,Seki C,Ikoma Y,Ichise M,Kawamura K,Takahata K,Moriguchi S,Nagashima T,Ishii T,Kitamura S,Niwa F,Endo H,Yamada M,Higuchi M,Zhang MR,Suhara T

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:The goal of this study is to determine the technical accuracy of segmental perfusion parameters assessed with quantitative cardiac PET imaging in the evaluation of coronary artery disease (CAD) in patients with stable angina. METHODS:A cohort of patients who participated in the EVINCI protocol underwent an eva...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Berti V,Sciagrà R,Neglia D,Pietilä M,Scholte AJ,Nekolla S,Rouzet F,Pupi A,Knuuti J

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Twelve years ago a meta-analysis evaluated the diagnostic performance of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in assessing musculoskeletal soft tissue lesions (MsSTL). Currently, PET/CT has substituted PET imaging; however, there has not been any published meta-analysis on the use o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Etchebehere EC,Hobbs BP,Milton DR,Malawi O,Patel S,Benjamin RS,Macapinlac HA

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate the potential of PEGylated (64)Cu-liposomes in clinical diagnostic positron emission tomography (PET) imaging and PEGylated (177)Lu-liposomes in internal tumor radiotherapy through in vivo characterization and dosimetric analysis in a human xenograft mouse model. MET...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Petersen AL,Henriksen JR,Binderup T,Elema DR,Rasmussen PH,Hag AM,Kjær A,Andresen TL

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:Cancer is still a clinical challenge, with many efforts invested in order to achieve timely detection. Unexplained elevated blood carcinoembryonic antigen levels are occasionally observed in an asymptomatic population and considered as a risk factor of cancers. The purpose of this study was to determine the val...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Li W,Yin W,Ou R,Chen T,Xiong L,Cheng D,Xie D,Zheng X,Xu Y,Zhao L

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Continuous bed motion has recently been introduced for whole-body PET/CT, and represents a paradigm shift towards individualized and flexible acquisition without the limitations of bed position-based planning. Increased patient comfort due to lack of abrupt table position changes may be another albeit still unp...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Schatka I,Weiberg D,Reichelt S,Owsianski-Hille N,Derlin T,Berding G,Bengel FM

更新日期：2016-04-01 00:00:00

abstract：:Cardiovascular diseases are the leading cause of death not only in Europe but also in the rest of the World. Preventive measures, however, often fail and cardiovascular disease may manifest as an acute coronary syndrome, stroke or even sudden death after years of silent progression. Thus, there is a considerable need ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bucerius J,Hyafil F,Verberne HJ,Slart RH,Lindner O,Sciagra R,Agostini D,Übleis C,Gimelli A,Hacker M,Cardiovascular Committee of the European Association of Nuclear Medicine (EANM).

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To evaluate the use of (18)F-FDG PET/CT for the assessment of tocilizumab (TCZ) as first-line treatment in patients with polymyalgia rheumatica (PMR). METHODS:Patients with PMR were prospectively enrolled in a multicentre clinical trial assessing TCZ therapy (the TENOR trial). The patients underwent FDG PET/CT...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Palard-Novello X,Querellou S,Gouillou M,Saraux A,Marhadour T,Garrigues F,Abgral R,Salaün PY,Devauchelle-Pensec V

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:While methods for imaging tumor hypoxia with positron emission tomography (PET) have been developed, optimal methods for interpreting and utilizing these datasets in the clinic remain unclear. In this study, we analyzed hypoxia PET images of head and neck cancer patients and compared imaging metrics with human ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Graves EE,Hicks RJ,Binns D,Bressel M,Le QT,Peters L,Young RJ,Rischin D

更新日期：2016-04-01 00:00:00